Document Type : Mini-Review
Department of Biology, Faculty of Science, Shiraz University, Shiraz, Iran
Department of Biological Science, Faculty of Science, University of Kurdistan, Sanandaj, Kurdistan, Iran
Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Golestan, Iran
One of the main investigated neurotrophin proteins in the brain of the mammalian is brain-derived neurotrophic factor (BDNF). Learning, memory, and cognitive function are affected by the decrease of BDNF. Curcuminoids and resveratrol as the main herbal polyphenols, have significant potential in neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. The neuroprotective activities of curcuminoids and resveratrol and its ability to enhance BDNF levels have been reported in several trials. BDNF/tyrosine receptor kinase B (TrkB) signaling pathway is upregulated by curcumin treatment. Nanoformulations of curcuminoids and resveratrol by biocompatible and biodegradable nanomaterials can be considered as a novel strategy with adequate efficacy to improve the bioavailability of these polyphenols. In this way, this mini-review has been tried to address recent progress about both micro and nanoformulations of curcuminoids and resveratrol.
- Curcumin at a concentration induces neurogenesis via increasing of the hippocampal BDNF level.
- The combination of curcumin with low-dose iron supplementation enhances ferritin formation and BDNF levels.
- Curcumin in combination with fluoxetine drug increases the cerebral expression of bdnf mRNA.
- Resveratrol augments BDNF serum amounts in brain parenchyma.
- Resveratrol increases the expression of hippocampal BDNF in mice having neuropathological brain changes.
- Resveratrol shows anti-inflammatory activity via regulating BDNF.