Document Type : Narrative Review
Authors
1
Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran
2
Department of Food Microbiology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
3
Department of Biology, Faculty of Science, University of Mazandaran, Babolsar, Iran
4
Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
5
Department of Basic Science & Pathobiology, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
10.22034/mnba.2023.417415.1047
Abstract
This review explores the various therapeutic properties of curcumin, derived from turmeric. Curcumin has demonstrated its potential in anti-inflammatory, neuroprotective, anticancer, and antimicrobial applications. It interacts with numerous proteins to combat inflammation and chronic diseases, such as arthritis. In terms of neuroprotection, it helps maintain the blood-brain barrier, reduces oxidative stress, and suppresses inflammation, offering hope for conditions like ischemia. For its anticancer effects, especially in nanoform, curcumin showcases its anti-inflammatory and antioxidant abilities. It inhibits cell proliferation, and invasion, and promotes apoptosis and autophagy. In the antimicrobial realm, curcumin effectively combats bacteria and viruses by disrupting their membranes, quorum sensing systems, and various mechanisms. In conclusion, curcumin's multifaceted properties make it a versatile therapeutic agent with potential in various health applications, including the use of micro or nanoformulations. Extensive research continues to uncover its full capabilities and benefits.
Graphical Abstract
Highlights
- Curcumin, identified for its neuroprotective properties, is associated with the inhibition of autophagic processes in the context of cerebral ischemia.
- Complexes of manganese with curcumin and their derivatives including diacetylcurcumin and ethylenediamine mimic SOD and penetrates the brain for control of brain neurotransmitters.
- Curcumin can cause disrupting bacterial cell membranes and inhibiting quorum sensing systems.
- There are the therapeutic promise of curcumin and its derivatives within micro- and nano-formulations.
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