Anticancer, antimicrobial, anti-inflammatory, and neuroprotective effects of bisdemethoxycurcumin: Micro and nano facets

Document Type : Narrative Review

Authors

• Sargol Aminnezhad ¹
• Maral Maghsoudloo ²
• Razieh Bagheri Shahzadeh Aliakbari ³

¹ Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran

² Institute for Micromanufacturing, Louisiana Tech University, Ruston, Louisiana, USA

³ College of Applied and Natural Sciences, Louisiana Tech University, Ruston, Louisiana, USA

Abstract

Graphical Abstract

Highlights

• Bisdemethoxycurcumin increases the permeability of bacterial membranes and inhibit the ATPase.
• Bisdemethoxycurcumin synergizes conventional antibiotics against MRSA.
• This metabolite shows the lower capacity to hinder TNF-induced NF-κB activation compared with curcumin and demethoxycurcumin.
• The anti-inflammatory and antiproliferative activity of bisdemethoxycurcumin may be related to its increasing effect on GSH levels.
• Bisdemethoxycurcumin ameliorates cognitive function, reduces oxidative stress and Aβ deposition, and augments the level of SIRT1 expression.

Keywords

• Turmeric
• Curcuminoids
• Bisdemethoxycurcumin
• Anti-acidogenic
• Radioprotective
• Nanoformulations

Main Subjects

• Biomedicine