Document Type : Narrative Review
Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran
Institute for Micromanufacturing, Louisiana Tech University, Ruston, Louisiana, USA
College of Applied and Natural Sciences, Louisiana Tech University, Ruston, Louisiana, USA
In recent years, various approved drugs have been developed deriving from natural sources with potential therapeutic applications. Among these natural metabolites, curcuminoids as phenolic compounds related to Turmeric have obtained great attention. Three main curcuminoids are bisdemethoxycurcumin, demethoxycurcumin, and curcumin with a variety of therapeutic potentials. These polyphenols exhibited numerous therapeutic activities involving anti-acidogenic, antioxidant, anti-inflammatory, anticancer, neuroprotective, antimicrobial, and radioprotective. Low bioavailability is the major limitation of these metabolites that can be ameliorated by novel biocompatible and bioavailable formulations. It must be noted that there are few investigations related to bisdemethoxycurcumin compared to curcumin and demethoxycurcumin, which we have discussed this metabolite in both micro and nanoformulations.
- Bisdemethoxycurcumin increases the permeability of bacterial membranes and inhibit the ATPase.
- Bisdemethoxycurcumin synergizes conventional antibiotics against MRSA.
- This metabolite shows the lower capacity to hinder TNF-induced NF-κB activation compared with curcumin and demethoxycurcumin.
- The anti-inflammatory and antiproliferative activity of bisdemethoxycurcumin may be related to its increasing effect on GSH levels.
- Bisdemethoxycurcumin ameliorates cognitive function, reduces oxidative stress and Aβ deposition, and augments the level of SIRT1 expression.