Novel formulations of hesperidin for antitumor, antimicrobial, and neuroprotective effects: A review

Document Type : Narrative Review

Authors

1 Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

2 Bioelectromagnetics Laboratory, School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran

10.22034/mnba.2023.394932.1030

Abstract

Hesperidin as a flavanone glycoside has various pharmacological activities. This phytoactive compound can damage the cell wall of bacteria and lead to a leakage of bacterial macromolecules by the generation of reactive oxygen species (ROS). Modulating cell cycle arrest, antiangiogenic, apoptosis, DNA repair, and antimetastatic have been indicated as the significant anticancer mechanisms of this flavanoglycone. Hesperidin in combination with anticancer drugs can be used as an adjuvant therapy. The neuroprotective activity of hesperidin resulted from the reduction of 5-HT/IL-β/TNF-α and the increase of BDNF/NE levels in the hippocampal. Moreover, neuropathologic degeneration and spinal cord injury-induced motor dysfunction may be ameliorated by the antioxidant and anti-inflammatory mechanism of hesperidin via the Nrf-2/HO-1 pathway. An effective micro- or nano-delivery system of hesperidin is required to reach its therapeutic target owing to the poor solubility and bioavailability of this bioactive agent. In this review, we have presented recent findings about novel micro- and nano-formulations of hesperidin.

Graphical Abstract

Novel formulations of hesperidin for antitumor, antimicrobial, and neuroprotective effects: A review

Highlights

  • Hesperidin can disrupt the cell wall of bacteria and cause a leakage of biological macromolecules such as proteins and DNA by the generation of ROS.
  • Cell cycle arrest, antiangiogenic, apoptosis, DNA repair, and antimetastatic of cancer cells are modulated by hesperidin.
  • As an adjuvant therapy, hesperidin in combination with conventional anticancer drugs can be used to reduce the severe side effects of chemotherapy.
  • The loading of hesperidin on AuNPs exhibited a significant reduction in of the secretion of TNF, IL-6, and IL-1β in the human breast cancer cell lines.
  • Neuropathological degeneration and spinal cord injury-induced motor dysfunction may be hindered by antioxidant and anti-inflammatory mechanism of hesperidin.

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© 2023 by the MNBA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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History

  • Receive Date: 05 May 2023
  • Revise Date: 15 July 2023
  • Accept Date: 15 July 2023

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