Therapeutic activities of the main bioactive compounds via modulating sirtuins: A review

Document Type : Narrative Review


1 Department of Biology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran

2 Department of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 College of Applied and Natural Sciences, Louisiana Tech University, Ruston, Louisiana, 71272, USA



Multiple cellular processes such as inflammation and apoptosis have been regulated by sirtuin (SIRT) proteins as highly conserved signaling proteins in eukaryotes, prokaryotes, and archaea. These proteins can be regulated under the effects of bioactive compounds, specifically ones isolated or derived from medical plant species. SIRT proteins can be targeted by various compounds such as apigenin, luteolin, fisetin, myricetin, ferulic acid, berberine, butein, malvidin, catechin, curcuminoids, and quercetin. The anti-inflammatory effect of these metabolites has been found to up-regulation of sirtuin expression. It should be noted that activation and inhibition of SIRT proteins have different therapeutic results. For example, activation of SIRT1 hinders oxidative stress, inflammation, and apoptosis in cells. In this review, we will discuss the therapeutic effects of these metabolites on cardioprotective, obesity, osteoarthritis, neurodegenerative, and other inflammatory and metabolic diseases by modulating sirtuins.

Graphical Abstract

Therapeutic activities of the main bioactive compounds via modulating sirtuins: A review


  • Activation of SIRT1 blocks oxidative stress, inflammation, and apoptosis.
  • Myricetin contributes to anti-inflammatory processes.
  • Berberine and quercetin can interact with SIRT3 and both SIRT2 and SIRT6, respectively.
  • Luteolin, as an activator of SIRT1 leads to the normal distribution of ER, Golgi complex, and mitochondria during postovulatory oocyte aging.
  • Upon luteolin treatment, inflammation in the liver reduced via regulating SIRT1/Nrf2/TNF-α signaling pathway.


Main Subjects

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