Document Type : Narrative Review
Department of Biology, Faculty of Science, Lorestan University, Khorramabad, Lorestan, Iran
Department of Biotechnology, Faculty of science, University of Maragheh, Maragheh, Iran
Faculty of Basic Sciences, Islamic Azad University OF Tehran Varamin Pishva Branch, Varamin, Tehran, Iran
The recurrence of fungal infections that occur during allogeneic bone marrow transplantation, cancer treatment, organ transplantation, and infected wounds has necessitated the discovery of more effective and better compatible antifungal and antibacterial compounds. A very limited number of antifungal and antibacterial compounds are effective against various forms of local and systemic fungal and bacterial infections. Considering the enormous potential of herbal and fungal metabolites for the isolation and screening of new antibiotics due to various pharmaceutical applications as an alternative source remains largely unknown. Endophytes are one of the microbial communities that live inside all plants without showing any symptoms, promising to produce a variety of biologically active compounds and new metabolites that are used in medicine, agriculture, and industrial sections.
- There are various metabolites of plants with antifungal and antibacterial activities.
- Secondary metabolites of plants may be the suitable alternatives to reduce side effects of conventional antibiotics.
- More comprehensive investigations are needed to optimize these metabolites in physiological conditions.
- Both micro and nano formulations should be considered in future studies.